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20 Best Things to do in Santa Fe, New Mexico & Top Attractions: Santa Fe, New Mexico's capital, is located on a Rio Grande tributary on the southwestern slopes of the snow capped Sangre de Cristo Mountains. The mingling of Native American, Spanish, Mexican, and Anglo-American cultural influences gives this fun and fascinating city its distinct atmosphere. Its picturesque streets and lanes, low adobe houses, beautiful Spanish colonial churches, and abundance of Native American arts and crafts and contemporary art have long drawn tourists.